Journal: Experimental Physiology

Article Title: Methodological comparison of fetal brain 1 H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

doi: 10.1113/EP093728

Figure Lengend Snippet: Individual metabolite levels were analysed using LCModel to investigate the impact of gestational age (109 ± 2 dGA, open circles, n = 7; 120 ± 5 dGA, filled squares, n = 10; and 139 ± 2 dGA, open squares, n = 5) on metabolite levels. Data were analysed by one‐way ANOVA with Bonferroni's correction for multiple comparisons, and are presented as the mean ± SD. P < 0.05 is considered statistically significant. Abbreviation: dGA, days gestational age.

Article Snippet: Furthermore, LCModel applies stronger priors (pre‐analysis biological information) on metabolite amplitudes and coupling patterns, whereas TARQUIN fits the data with fewer constraints (Poullet et al., ; Provencher, ).

Techniques:

Journal: Experimental Physiology

Article Title: Methodological comparison of fetal brain 1 H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

doi: 10.1113/EP093728

Figure Lengend Snippet: Representative spectra from LCModel output (a, b) alongside results from TARQUIN analysis (c, d) in the same animal.

Article Snippet: Furthermore, LCModel applies stronger priors (pre‐analysis biological information) on metabolite amplitudes and coupling patterns, whereas TARQUIN fits the data with fewer constraints (Poullet et al., ; Provencher, ).

Techniques:

Journal: Experimental Physiology

Article Title: Methodological comparison of fetal brain 1 H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

doi: 10.1113/EP093728

Figure Lengend Snippet: Comparison of total N‐acetylaspartate (tNAA) (a), total Choline (tCho) (c) and total Creatine (tCr) (e) levels analysed using TARQUIN (filled circles) and LCModel (open squares) at a gestational age of 109 ± 140 days ( n = 19). Agreement between TARQUIN and LCModel for tNAA (b), tCho (d) and tCr (f) was assessed using Bland–Altman plots, showing the differences between measurements versus their averages. Statistical analysis was performed using Student's paired t ‐test and Bland–Altman bias and agreement test. P < 0.05 was considered statistically significant.

Article Snippet: Furthermore, LCModel applies stronger priors (pre‐analysis biological information) on metabolite amplitudes and coupling patterns, whereas TARQUIN fits the data with fewer constraints (Poullet et al., ; Provencher, ).

Techniques: Comparison

Journal: Experimental Physiology

Article Title: Methodological comparison of fetal brain 1 H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

doi: 10.1113/EP093728

Figure Lengend Snippet: The relationship between the Signal to Noise Ratio and total N‐acetylaspartate, total Choline and total Creatine measured by TARQUIN (filled circles) and LCModel (open squares) at a gestational age of 109 ± 140 days ( n = 19). The relationship was analysed by a simple linear regression. P < 0.05 was considered statistically significant.

Article Snippet: Furthermore, LCModel applies stronger priors (pre‐analysis biological information) on metabolite amplitudes and coupling patterns, whereas TARQUIN fits the data with fewer constraints (Poullet et al., ; Provencher, ).

Techniques: